64Cu-DOTA as a surrogate positron analog of Gd-DOTA for cardiac fibrosis detection with PET
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منابع مشابه
Characterization of 64Cu-DOTA-conatumumab: a PET tracer for in vivo imaging of death receptor 5.
UNLABELLED Conatumumab is a fully human monoclonal antibody that binds to and activates human death receptor 5 (DR5; also known as TRAIL receptor 2). The purpose of this study was to characterize (64)Cu-labeled conatumumab as a PET tracer for imaging DR5 in tumors. METHODS DOTA-conatumumab was synthesized by incubating conatumumab with 2,2',2″-(10-(2-(2,5-dioxopyrrolidin-1-yloxy)-2-oxoethyl)-...
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UNLABELLED (64)Cu-DOTA-AE105 is a novel positron emission tomography (PET) tracer specific to the human urokinase-type plasminogen activator receptor (uPAR). In preparation of using this tracer in humans, as a new promising method to distinguish between indolent and aggressive cancers, we have performed PET studies in mice to evaluate the in vivo biodistribution and estimate human dosimetry of ...
متن کاملTrivalent Gd-DOTA reagents for modification of proteins.
The development of novel protein-targeted MRI contrast agents crucially depends on the ability to derivatise suitable targeting moieties with a high payload of relaxation enhancer (e.g., gadolinium(iii) complexes such as Gd-DOTA), without losing affinity for the target proteins. Here, we report robust synthetic procedures for the preparation of trivalent Gd-DOTA reagents with various chemical h...
متن کاملNew fluorinated Gd-AspGlyMe-DOTA complexes for F-MRI
Introduction F-MRI gets an interesting method for molecular imaging. The high MR sensitivity and very low natural abundance in living organisms makes fluorine interesting in medical diagnostic. Mostly perfluorinated contrast agents like perfluorocarbons will be used. Synthesis of fluorinated Gd-contrast agents allow to record Fimages without any background signals and additional classical H-MR ...
متن کاملPositron Emission Tomography Imaging of CD105 Expression with a 64Cu-Labeled Monoclonal Antibody: NOTA Is Superior to DOTA
Optimizing the in vivo stability of positron emission tomography (PET) tracers is of critical importance to cancer diagnosis. In the case of (64)Cu-labeled monoclonal antibodies (mAb), in vivo behavior and biodistribution is critically dependent on the performance of the bifunctional chelator used to conjugate the mAb to the radiolabel. This study compared the in vivo characteristics of (64)Cu-...
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ژورنال
عنوان ژورنال: Nuclear Medicine Communications
سال: 2016
ISSN: 0143-3636
DOI: 10.1097/mnm.0000000000000417